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Unlike the body's natural GLP-1, which breaks down within minutes, these medications are designed to remain active for much longerranging from once-daily to once-weekly formulations
DOI: 10.1210/en.2004-1286
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They are running or planning to run weekly retatrutide doses above 5mg per week where the 10mg vial provides meaningful efficiency advantages over the 5mg vial
Understanding these pathways explains why the clinical data looks so different from semaglutide and tirzepatide
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