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FIGURE 2 5.1 Exercise regulates iron metabolism Iron levels in specific organs such as the brain, skeletal muscles, intestines, and liver gradually increase with age (Ward et al., 2014)

Mechanistic studies further support the rationale for combination therapy

MUSE cells (Multilineage-differentiating Stress Enduring cells) are a special kind of stem cell first identified by researchers in Japan

Genes under the control of E2F encompass cell cycle regulators like Cyclin E and Cdc25A, as well as genes responsible for DNA replication [26]

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