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Eligible participants were adults without diabetes with a BMI of at least 30 kg/m, or at least 27 kg/m with hypertension or dyslipidaemia

Laboratory studies reveal TB-500 reduces production of inflammatory mediators including TNF- and IL-1 by 55% while enhancing anti-inflammatory IL-10 and TGF- expression, creating balanced immune responses that clear damaged tissue while supporting regeneration

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The specific deletion of Mfn2 in mouse liver will lead to liver inflammation and lipid metabolism disorders

The key is patience and consistency