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The theoretical risk requires a lifetime contraindication in patients with a personal or family history of medullary thyroid cancer (MTC) or menin-2 (Mary and Curtis 2010

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A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders

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It is proposed that this non-invasive risk score be used in a primary care clinic and non-hepatology settings to identify individuals at high risk of advanced liver disease with FIB-4 scores greater than 2.67 and refer them to hepatology