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This cycling approach serves multiple purposes: it prevents potential receptor desensitization, maintains copper homeostasis, and allows assessment of results before continuing

Am J Clin Nutr 1991

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PMCID: PMC3005481

Although THC possesses neuroprotective antioxidant properties through non-CB1R pathways [33], it also upregulates plasma inflammatory cytokines [34], increases vulnerability to ischemic stroke in young people [35], increases mitochondrial dysfunction [36, 37] and alters gene pathways associated with mitochondrial oxidative phosphorylation [38]