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Patient matching was performed using propensity score matching (PSM), and the balance of potential confounding variables between the GLP-1 agonists and control groups after PSM was assessed using standardized mean differences (SMD)

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Are GLP-1s Performance-Enhancing Drugs

Active GLP-1 (7-36) amide Levels This means that GLP-1 (7-36) amide is present at low physiological concentrations, making accurate measurements extremely difficult, particularly in fasted subjects who already have low levels of active GLP-1 2

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The PIONEER-6 trial suggests cardiovascular benefit of oral semaglutide in patients with diabetes compared to placebo