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De Araujo is finding that adverse reactions might be caused by how the drug differs from the naturally occurring peptide hormone: The hormone acts mostly locally and degrades quickly, while the medicine works mainly on the brain and is designed to stick around in the body
So, that was their hypothesis
Cells 10:3273
Although different pathophysiological mechanisms lead to metabolic syndrome, it is associated with obesity through dysfunction of adipose tissue as the main contributor to obesity and subsequent complications
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the latter is bioactive, bypassing conversion needs
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