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Int J Mol Sci 2019;20
9- McKie AT et al
GLP- 1 receptor agonism has not been thoroughly studied, but it has been demonstrated in certain cell lines to activate additional G-protein subunits and alternative downstream signaling pathways [60,61,62] GIP Receptor Signaling The mature 42 amino acid GIP attaches itself to the b cell surface and activates its cognate receptor, the GIP receptor
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This new molecule, by acting synergistically on combined systems known to be altered in T2DM [33, 34], could indeed expand the therapeutic potential of GLP-1 agonists/analogues, suggesting new scenarios in terms of improving glycemic control, weight management, and hopefully providing protection against chronic micro-macrovascular complications and not only limited to hepatic complications
Furthermore, several transcription factors, such as Neurod1, Rfx6, Arx, Foxa1, Foxa2, Pax4, and Pax6 regulate the differentiation of EEC subpopulations [24] (Fig
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