Blocking antibodies against PD-L1 and PD-L2 hindered regulatory T-cells protective function, leading to AKI via ATN [189, 190]
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Mast cells are the immune system's first responders, heavily concentrated in tissues that interface with the outside world, such as the lungs, sinuses, skin, and gut lining
Int J Androl 13:1725
To reconcile the findings that both GIPR antagonists and GIPRAs reduce body weight, it is possible that physiological GIPR activity plays a permissive role in adipose tissue synthesis, while pharmacologically enhanced GIPR activity may reduce body weight through a different mechanism in the brain