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Moreover, this oxidative stress often diminishes AMP-activated protein kinase (AMPK) activity, which then reduces the expression of PPAR coactivator (PGC)-1, a pivotal regulator of mitochondrial biogenesis, thus exacerbating the decline in the mitochondrial mass [167]
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Presented for research literature review only Kadakia R et al
Selenium and selenium species in the etiology of Alzheimers dementia: the potential for bias of the case-control study design
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