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Malaguarnera, M., Pistone, G., Astuto, M., Vecchio, I., Raffaele, R., Lo, Giudice E., and Rampello, L
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However, the significant weight changes usually come later on, typically after the 12-week mark
Weight loss in women with PMOS is super impactful in improving both reproductive and metabolic health, Kim said
The Phase 2 trial enrolled participants with obesity and evaluated multiple dose levels over 48 weeks: 1 mg dose: 8.7% average body weight reduction 4 mg dose (escalated from 2 mg): 17.1% average body weight reduction 8 mg dose (escalated from 2 mg): 22.8% average body weight reduction 12 mg dose (escalated from 2 mg): 24.2% average body weight reduction Placebo: 2.1% average body weight reduction Those Phase 2 numbers were striking enough
Each weekly injection adds to the circulating retatrutide level, and by week two or three, most people notice more consistent appetite suppression
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