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SGLT2 Inhibitors (SGLT2i) Kidney-Focused Regulation Mechanism: Works through the kidneys, independent of insulin signaling

Unlike thalidomide, which was once promoted for its extreme safety prior to the discovery of its teratogenicity, acetaminophen has a long history of serious side effects associated with its use (Table 1)

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However, given the observational nature of the study and the potential for residual confounding, these findings should be interpreted with caution and do not definitively establish a detrimental biological effect