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Up to 55% of patients developed anti-drug antibodies [65], which were associated with systemic allergic reactions in approximately 5% of cases and injection-site hypersensitivity, including anaphylaxis, which necessitated early trial termination [66, 67]
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This work was partly supported by a Diabetes Australia Research Program grant and the Victoria State Government Operational Infrastructure Support Program, who did not play a role in study design/conduct, analysis/interpretation of data, or manuscript preparation
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These DSBs initiated repair processes, predominantly through the NHEJ pathway, enabling the integration of the linearized donor DNA at the genomic DSB site with a predetermined orientation 5
specifically that glutathione can shift the production of eumelanin to pheomelanin and decrease the production of the enzyme tyrosinase, both of which support a gradual reduction in hyperpigmentation and uneven skin tone
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