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The 2026 landscape is complicated by unprecedented regulatory uncertainty, particularly in the United States, the authors wrote

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Since these medications have established safety profiles in approved metabolic indications, researchers feel they could potentially be repurposed for addiction treatment more quickly than entirely new drugs, although safety and tolerability in people with alcohol or substance use disorders still require dedicated testing

[19] further suggest that decreased levels of carnitine in the eye in experimental diabetes (as reported by Pessotto et al

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