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Surgical procedures or conditions that affect the gut, such as gastric bypass surgery or celiac disease, can prevent intrinsic factors from binding to B12 and prevent the body from breaking it down before absorbing the vitamin

If you skip titration steps, you will likely push yourself through the threshold for significant nausea and vomiting, which is both miserable and a common cause of protocol discontinuation

However, its important to note that 24 weeks, while substantial for clinical trials, represents a relatively limited timeframe for assessing lifetime exposure safety

The physician can't separately bill the administration code in a facility setting

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