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Erythrocytes: canonical and non-canonical functions Oxygen (O 2 ) is an indispensable gas required in humans for multiple reactions and primarily used as the terminal electron acceptor in the mitochondrial electron transport chain at the level of complex IV to generate the proton electrochemical gradient necessary for adenosine triphosphate (ATP) synthesis by oxidative phosphorylation [42]

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Dose-Response Relationships In animal stroke models, gene expression changes occurred 1-24 hours post-administration, but whether similar timing applies to psychiatric effects is unknown