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Maintaining weight loss is itself a clinically meaningful outcome

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Treating obesity is not just a matter of willpower for some people, Anekwe says, and the results underscore what happens when a helpful weight-loss intervention is interrupted

The NEJM editorial accompanying the SURMOUNT-1 trial (N=2,539, tirzepatide 15 mg, 22.5% weight loss at 72 weeks) noted that access barriers to branded agents have driven patients toward unverified alternatives, and called for "pharmacy-level quality standards to be rigorously enforced before injectable peptides reach patients." [4] Patients who choose to use any compounding pharmacy should report adverse events to FDA MedWatch at fda.gov/safety/medwatch

Most individuals find this adaptation manageable, particularly when supported by healthcare providers who understand the psychological dimensions of weight loss

Iowa lawmakers are thinking about ordering a cost-benefit analysis before making the commitment