Some users report fewer illnesses and faster recovery when sick
Only ~ 5% of the liver-derived bile salts and bile acids enter the large intestine during each enterohepatic circulation
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A large-scale double blind placebo trial would need to be done and validate the clinical benefit of PDE-5 inhibitor, but current research is promising ( Table 2 )
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However, compared to small molecule inhibitors, the discovery of small molecule activators is much more challenging (Zorn and Wells, 2010)