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Cardiovasc Med

This may be due to the existence of an intact IGF1R in both WT and knockin mice as well as effects from both ligands, insulin and IGF-1, which could at least partially compensate for their downstream signaling effects

Islam K, Islam R, Nguyen I, Malik H, Pirzadah H, Shrestha B, et al

On the other hand, deficient cortisol levels, also known as hypocortisolism or Addison's disease, can also affect methylation and detoxification

However, these tend to be dose dependent, self limiting, and transient once your body acclimates