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Certain ones additionally carry approval to reduce the risk of heart attack and stroke in people with diabetes and heart disease valuable for seniors who often manage several conditions at once
However, it is also crucial to consider the receptor's polymorphism and how loss-of-function variants are associated with unpigmented skin, UV sensitivity, and a heightened skin tissue damage risk due to impaired melanization and suboptimal DNA repair mechanisms
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2025;48(1 Suppl 1):S181206
A series of transporters primarily acting in the kidney is responsible for the control of UA in the blood 3 , with URAT1 (coded by SLC22A12) responsible for most kidney reabsorption into the blood and ABCG2 (or breast cancer resistance protein, BCRP) mainly involved in secretion into urine
Regardless of the exact cause, the emotional response is often the same: shock, confusion, and a strong desire for reassurance
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