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This includes gradually increasing the dose every four weeks, following a reduced-calorie diet, and engaging in at least 150 minutes of physical activity per week

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In a phase 2 study in people with obesity (without T2D), retatrutide (doses 1 to 12 mg) has led to a dose-dependent WL up to 24.2% at the end of the 48-week treatment period compared to 2.1% with placebo [81]

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Separately, research shows the peptide promotes growth hormone receptor expression in fibroblasts and myosatellite cells, supporting collagen synthesis and tissue remodeling at wound sites