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It is thought that its primary action is on the liver and it was demonstrated that it inhibits hepatic gluconeogenesis both in vitro and in vivo in a redox-dependent manner without concomitant increases in plasma insulin concentrations

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Meta-analyses show berberine reduces body weight by approximately 2-3 kg (4.5-6.5 pounds) over 12-16 weeks, with improvements in fasting blood glucose, insulin sensitivity, and lipid profiles

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Target A1C Levels The American Diabetes Association (ADA) recommends most diabetic patients attempt to achieve an HbA1C level of about 7% or less (ADA 2021a)