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GH pulse shape and IGF-1 response are what drive most downstream physiology, and neither peptide has published long-term human outcome data for body composition, strength, or longevity endpoints
A possible explanation for these conflicting results is that GIPR is subject to less desensitization than GLP-1R
Back Manalac, T (23 Dec 2024) '7 Indications for GLP-1s beyond weight loss', BioSpace
The biological adaptations that drive weight regain (increased ghrelin, decreased leptin, reduced metabolic rate) are strongest immediately after weight loss
Rudman D, Williams PJ
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