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Description

Classic anticonvulsants such as pheytoin and carbamazepine had a relatively high EID ( 1:50,000)

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Indeed, deficiency in ribose-5-phopshate isomerase is considered to be second rarest disorder world-wide

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Modifying the N-terminal amino acid, particularly the second residue, has been shown to reduce cleavage by DPP-IV

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