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Figures based on published phase-3 trial data

NAION Vision Loss and Emerging Claims Additional severe medical conditions recognized within the MDL framework include: NAION vision loss : Sudden, painless, permanent blindness affecting over 140 MDL plaintiffs with studies showing a 4-fold increased risk for diabetics and 7-fold risk for weight loss patients Deep vein thrombosis (DVT) : Research demonstrating 66% increased risk according to published meta-analyses affecting thousands of Ozempic users Pulmonary embolism : Life-threatening blood clots traveling to lungs requiring emergency intervention Pancreatitis : Severe pancreatic inflammation potentially progressing to necrotizing pancreatitis requiring intensive care Gallbladder disease : Requiring cholecystectomy surgery in many cases with average surgical costs of $10,000-$20,000 for laparoscopic procedures Acute kidney injury : Resulting from severe dehydration and persistent vomiting requiring dialysis in severe cases Diabetic retinopathy progression : Worsening of existing eye conditions documented in multiple clinical studies Potential wrongful death claims : Fatal complications from untreated gastrointestinal injuries or systemic complications The American Academy of Ophthalmology recognizes NAION as the most common acute optic neuropathy in adults over 50, with semaglutide users showing a fourfold increased risk for diabetics and sevenfold increased risk for weight loss patients according to the landmark 2024 Mass Eye and Ear study

The optic nerve is responsible for transmitting visual information from the eye to the brain

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If the data remains positive, a New Drug Application (NDA) could be submitted to the FDA in late 2026 or early 2027, with approval potentially coming in 2027