Glutathione Reductase reduces oxidized glutathione (GSSG) to reduced glutathione (GSH) in the presence of NADPH
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Recently, despite administration of NAC 600 mg po tid, a sustained increase in GSH concen-trations could not be found in the plasma, bronchoalveolar lavage fluid, or lung tissue of patients with chronic obstructive pulmonary disease
Indeed, while in many cases it would be desirable or crucial to specifically target a particular GST isozyme or polymorphic form, this is hardly achievable with the molecules synthesized and investigated so far