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2.2 Substrate-specific metabolic overload (02 h post-meal) Excess glucose engages canonical insulin signaling [insulin receptor substrate (IRS)phosphoinositide 3-kinase (PI3K)protein kinase B (Akt)] to drive glucose transporter type 4 (GLUT4) translocation in skeletal muscle and adipose tissue

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However, during clinical trials, researchers found that it also had a significant effect on weight loss