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Proc Nutr Soc 81(1):108118

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V.SimoesH

Discussion Mitochondrial dysfunction, redox imbalance, and excessive ROS generation are central pathological features of PD, particularly in dopaminergic regions of the nigrostriatal pathway [47]

The association of ROS with neuronal degeneration in PD is further substantiated by modeling the Parkinsonian phenotypes in animals through 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, 1,1-dimethyl-4,4-bipyridinium dichloride (paraquat), or 6-hydroxydopamine (6-OHDA), those are known of elevate the oxygen free-radicals in the cell 18