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Journal of Pharmacology and Experimental Therapeutics

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Nitrous oxide can also deplete B12 levels

doi: 10.1080/15592324.2025.2486076 73 JadhavPAThomasABPathanMKChaudhariSYWavhaleRDChitlangeSS

NHS approach to B12 deficiency: NICE Clinical Knowledge Summaries recommend investigating B12 deficiency in patients presenting with macrocytic anaemia, unexplained neurological symptoms, or risk factors including pernicious anaemia, gastrectomy, malabsorption disorders, metformin use, proton pump inhibitors, or nitrous oxide exposure

Some researchers prefer 0.5 mL (50-unit) insulin syringes for very small doses