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Much of this evidence comes from preclinical models, so human conclusions remain limited

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This complex metabolic disorder is accompanied by an increase in local and systemic inflammatory mediators, such as proinflammatory cytokines [e.g., interleukin (IL)-6 and IL-8 and tumor necrosis factor-alpha (TNF-)] [9, 10]

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Research indicates that higher estrogen levels are associated with increased glutathione levels, suggesting a complex interplay between these two substances

Bibcode:2007PNAS..10419351S