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does the existence of two SHMT isoforms in the body serve to support activity of thymidylate biosynthesis in varying UV environments

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doi: 10.1016/S0145-2126(98)00154-4 28 PaninaSBPeiJBaranNTjahjonoEPatelSAlatrashGet al

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Although targeting macropinocytosis could be a key strategy for overcoming resistance to glutamine uptake blockade, further studies are necessary to examine whether macropinocytosis can overcome tumor cell resistance to glutamine antimetabolites or GLS inhibitors that target enzymes involved directly in glutamine metabolism