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GLP-1 receptor sequence and expression pattern differ enough between rodents and primates that potency and tissue distribution do not transfer cleanly, and rodent food intake data in particular has a poor record of predicting magnitude in other species
One person may eat 1,800 calories a day and be fine, while another may be overweight, he explained
Food and Drug Administration (FDA) has not approved it yet
However, patients with stage 4 or 5 kidney disease require careful evaluation and may need dose adjustments
17(12):e1003228 Doumouras AG, Hong D, Lee Y, Tarride JE, Paterson JM, Anvari M (2020) Association between bariatric surgery and all-cause mortality: a population-based matched cohort study in a universal health care system
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