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It was her research and development of Novo Nordisk's first daily GLP-1 shot for diabetes (liraglutide, approved in the US in 2010) that would spur the development of those more powerful, longer-lasting weekly shots, which she also oversaw

Ipamorelin is a synthetic peptide that selectively stimulates growth hormone release without affecting other hormones like cortisol

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Second, the nested casecontrol design with propensity matching enabled efficient evaluation of multiple relatively uncommon outcomes while strengthening internal validity and supporting a clear temporal relationship between GLP-1RA exposure and SUD diagnoses