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SCFAs have protective cardiovascular effects, while TMAO and lipopolysaccharides (LPS) from gut dysbiosis exacerbate cardiovascular diseases by promoting inflammation and endothelial dysfunction [40]

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Common criteria include: type 2 diabetes diagnosis with inadequate control on other medications, or BMI 27 kg/m with weight-related comorbidities (hypertension, sleep apnea, cardiovascular disease)