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Enhanced Stability : Modifications to its structure improve its efficacy and half-life, allowing for once-weekly dosing ( 6 )

First, failure occurring at supraphysiologic exposure levels is a strong indicator of pharmacologic rather than biological failure

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The aqueous phase was dried using vacuum centrifugation, and the sample was reconstituted with 50 L of 50% methanol prior to LCMS/MS analysis

Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2