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Figure 4: Changes in body weight in A) lean mice and B) obese mice and changes in food intake in C) lean mice and D) obese mice, across the three different experimental treatment groups

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Due to abnormal intracranial PLP transport in patients with TNSALP mutations, there is insufficient neurotransmitter synthesis in the brain, which eventually contributes to PL-dependent seizures, usually preceding the onset of skeletal changes [41, 49,50,51,52]

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Cyanocobalamin Injection, USP is a sterile solution of cyanocobalamin for intramuscular or subcutaneous injectionEach vial also contains Sodium Chloride, 0.9%Benzyl Alcohol, 1.5%, is present as a preservativeStore at controlled room temperature of 20 to 25 degrees Celsius (68 to 77 degrees Fahrenheit)Protect From Light