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Dapagliflozin plus exenatide on patients with type 2 diabetes awaiting bariatric surgery in the DEXBASU study
However, combining these medications should be done under strict medical supervision to avoid potential risks such as hypoglycemia, where blood sugar levels drop too low
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In DM, hyperglycemia-induced ROS production worsens beta-cell failure and insulin resistance through pathways such as the AGE-RAGE signaling, protein kinase C (PKC) activation, and the polyol pathway
Patients should always follow medical guidance and report any concerns to their healthcare provider
A key research question is whether this prolonged, supra-physiological stimulation leads to long-term desensitization or downregulation of the GHRH or GHS-R receptors
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